Clinical Studies
Non-invasive hemodynamic profiling of patients undergoing hemodialysis-a multicenter observational cohort study
Authors: Keren Doenyas-Barak, Marcia H. F. G. de Abreu, Lucas E. Borges, David Pereg, Ilya Litovchik, Shmuel Fuchs and Sa’ar Minha Conclusion: Non-invasive assessment of patients’ response to HD provides relevant hemodynamic information that exceeds
The value of non-invasive measurement of cardiac output and total peripheral resistance to categorize significant changes of intradialytic blood pressure: a prospective study
Authors: Yunlin Feng, Yurong Zou, Yifei Zheng, Nathan W Levin, Li Wang Conclusion: This technology provides multi-dimensional insight into intradialytic hemodynamic parameters, which may be more informative than blood pressure only. Using hemodynamic parameters to
Bioimpedance based clinical decision making in hemodialysis patients decreases episodes of hypotension
Authors: Katzir, Zeev; Petrohno, Oksana; Leiba, Adi; Sharipov, Tatiana; Rubin, Olga; Gaber, Yahya; Hausman, Michel Conclusion: These preliminary results suggest that clinical decision-making based on bio-impedance monitoring, when applied to new HD patients from the
Directed antihypertensive therapy improves growth restriction and perinatal mortality in women with chronic hypertension.
Authors: David Chaffin, Jesse Cottrell, Kelly Cummings, David Jude. Maternal Hypertension Center at Cabell Huntington Hospital, Virginia, USA Conclusion: Impedance cardiography-directed antihypertensive therapy during early pregnancy allows for informed initiation and titration of blood pressure
Comparison of non-invasive hemodynamic monitoring by bioimpedance and echocardiography in cardiac intensive care unit patients
Authors:N. Kofman; A.;A. Rotmansh; E. Kalmanovich Conclusion: Even in the hands of cardiologists trained in performing echocardiographic hemodynamic evaluations, the measurement consistency is relatively low. Evaluation done by NICaS provides a much closer result correlation.
Non-invasive hemodynamic evaluation following TAVI for severe aortic stenosis
Authors: K Orvin, T Grinberg, R Kornowski, Maya Wiessman, Yaron Aviv, Leor Perl CONCLUSION: A unique pattern of short and longer-term adaptive hemodynamic changes was demonstrated using the NICaS system among patients undergoing TAVI. These
Lack of Concordance Between Parameters Defining Cardiogenic Shock in Patients With ST Elevation Myocardial Infarction
Authors: Triston Eastman, Mirna Ragheb, Mullein Thorleifson, Brett Hiebert, Kunal Minhas, Malek Kass, Amir Ravandi and Ashish Shah Conclusion: Our study is the first to describe poor congruity between the current parameters defining CS. Such
Non-Invasive Hemodynamic Whole-Body Bioimpedance Indices for the Early Detection of Cancer Treatment-Related Cardiotoxicity: A Retrospective Observational Study
Authors: Nili Schamroth Pravda, Shaul Lev , Osnat Itzhaki Ben Zadok, Ran Kornowski, Zaza Iakobishvili Conclusion: GGI, a parameter measured by WBI, can reliably correlate to biomarker evidence of heart failure in patients after chemotherapy.
Accurate noninvasive continuous monitoring of cardiac output by whole body electrical bioimpedance
Authors: Gad Cotter , Yaron Moshkovitz, Edo Kaluski, Amram J Cohen, Hilton Miller, Daniel Goor, Zvi Vered The results of the study indicate that the measurements taken by the NICaS are accurate in rapid, noninvasive
The effect of intradialytic volume change on cardiovascular hemodynamics
Authors: Nathan W Levin MD FACP1, Marcia H. F. G de Abreu MD2, Lucas E. Borges MD, Helcio A. Tavares Filho, Rabia Sarwar, MD3Surendra Gupta, MD, Tahir Hafeez MD, Shaul Lev, MD, Caroline Williams, RD,
Assessing patent ductus arteriosus (PDA) significance on cardiac output by whole‑body bio‑impedance
Authors: Ruth Rafaeli Rabin , Ilya Rosin , Avraham Matitiau , Yael Simpson , Orna Flidel-Rimon Conclusion: We found significant differences in hemodynamic parameters between premature infants with and without significant PDAs. We believe these
Hemodynamic response to fluid removal during hemodialysis: categorization of causes of intradialytic hypotension
Authors: Nathan W Levin , Marcia H F G de Abreu , Lucas E Borges , Helcio A Tavares Filho , Rabia Sarwar , Surendra Gupta , Tahir Hafeez , Shaul Lev , Caroline Williams
The Clinical Research of NICaS for Monitoring Changes of Cardiac Function in Patients with Sepsis (part 2)
Authors: Zhu Yan Second Military Medical University CONCLUSION: (1) In patients with sepsis thrombocytopenia, a high SOFA score indicates that the patient is in critical condition and the prognosis is poor. (2) sepsis patients with
The Clinical Research of NICaS for Monitoring Changes of Cardiac Function in Patients with Sepsis (two part study – part 1)
Authors: Zhu Yan Second Military Medical University CONCLUSION: NICaS can measure the cardiac output and stroke volume in sepsis patients as accurate as ultrasonic Cardiogram, and the exclusive GGI figure NICaS provides has a positive
Application of Impedance Cardiac Output Monitoring System in AMI Patients After PCI
Authors: Guo Longzhe, Ning Wenlong, Liu Fei, Wang Xueyan, Xin Chuanyou, Zhong Lijuan, Zhou Guangjun, Bao Haibo, Du Aijun. Conclusion: NICAS can more accurately assess the patient’s cardiac function, thereby improving the overall treatment effect.
A Novel Hypertension Management Algorithm Guided by Hemodynamic Data
Authors: Barbara Greco, Yossi Chait, Brian Nathanson, Michael J. Germain Conclusion: This pragmatic continuous quality improvement program reveals the feasibility and effectiveness of a hemodynamically directed management algorithm to individualize hypertension management in busy nephrology
Consistency between Impedance Technique and Echocardiogram Hemodynamic Measurements in Neonates
Authors: Wenshen Wu, Sulian Lin, Caixuan Xie, Jianbo Li, Jingen Lie, Shuyi Qiu Conclusion: Agreement between the IT and ECHO in the cardiac output measurement appeared acceptable. However, the accuracy and precision of the IT
Non-Invasive hemodynamic monitoring in TAVI-patients reveals more pronounced early in-hospital circulatory recovery for low-gradient aortic stenosis
Authors: Birgit Markus, Holger Ahrens, Bernard Schieffer and more. Conclusion: NICaS monitoring represents an accurate non-invasive bedside tool to discriminate adaptive circulatory changes in subgroups of aortic stenosis patients subjected to TAVI. Hemodynamic parameters recovered
Early post-stress decrease in cardiac performance by impedance cardiography and its relationship to the severity and extent of ischemia by myocardial perfusion imaging
Authors: Ronen Goldkorn, Alexey Naimushin, Eli Rozen & Dov Freimark Conclusion: The results of the present study suggest that the immediate post-stress changes in several hemodynamic parameters as detected by the NICaS can be used
The Hemodynamics of Labor in Women Undergoing Vaginal and Cesarean Deliveries as Determined by Whole Body Bioimpedance
Authors: Eran Ashwal, Shiri Shinar, Sharon Orbach-Zinger, Shaul Lev , Roi Gat, Liron Kedar , Yehuda Pauzner , Amir Aviram , Yariv Yogev , Liran Hiersch Conclusion: Whole-body bioimpedance can be used effectively to assess
Intradialytic exercise increases cardiac power index
Authors: Brent Momb, Samuel Arlington Headley, Tracey Matthews, Michael J. Germain In conclusion, exercise during dialysis may decrease the likelihood of experiencing ischemic or hypotensive events by enhancing myocardial perfusion through increasing CPI and ̇Q.
Neonatal and Pediatric General and Cardiac Anesthesia and ICU
Bari Pediatric Hospital Experience-Italy Authors: R Beck , L Milella , C Labellarte We compared the NICaS data in double-check with a pediatric algorithm using a CardioQ ultrasonograph cardiac evaluation device (CardioQ, Deltex medical; terminus
Impedance cardiographt in the evaluation of the hemodynamic profile in dilated cardiopathy
Authors: María Carolina Duarte Martínez, Carlos Andres Peñaherrera, Ernesto Peñaherrera Patiño A cross-sectional study in a public hospital in Ecuador. Chronic arterial hypertension is the main cause of dilated heart disease in our country. These
The role of noninvasive hemodynamic monitoring in the evaluation of acute and severe pesticide poisoning
Authors: Gao X,Chen ML, Wang YF, Zhu QQ, Zhu BY, Wang P,Kong FT, Conclusion: NICaS can effectively monitor the hemodynamic indexes of patients with acute pesticide poisoning. For the full article click here
Comparison of stroke volume measurements during hemodialysis using bioimpedance cardiography and echocardiography
Authors: Michael J. Germain,Jyovani Joubert,Daniel O’Grady,Brian H. Nathanson,Yossi Chait,Nathan W. Levin NICaS SV measurements are similar to and strongly correlated with Echo SV measurements. This suggests that noninvasive NiCaS technology may be a practical method
Directed antihypertensive therapy improves growth restriction and perinatal mortality in women with chronic hypertension
Authors: David Chaffin, Jesse Cottrell, Kelly Cummings, David Jude Conclusion: Impedance cardiography-directed antihypertensive therapy during early pregnancy allows for informed initiation and titration of blood pressure medications. This low-cost and non-invasive test should be considered
A Phase 2a dose-escalation study of the safety, tolerability, pharmacokinetics and hemodynamic effects of BMS-986231 in hospitalized patients with heart failure with reduced ejection fraction
Authors: Cristina Tita , Edward M Gilbert , Adrian B Van Bakel , Jacek Grzybowski , Garrie J Haas , Mohammad Jarrah , Stephanie H Dunlap , Stephen S Gottlieb , Marc Klapholz , Parag
Continuous non-invasive measurement of stroke volume and cardiac index in infants and children: comparison of Impedance Cardiography NICaS vs CardioQ method
Authors: R Beck 1, L Milella 2, C Labellarte 3 Conclusion: Good correlation was observed in pediatric patients for CI measured with NICaS® in comparison with CardioQ® device. Continuous non-invasive monitoring of NI-CI can be
Validation of Non-invasive Cardiac System (NICaS) Derived Stroke Volume With Cardiac Magnetic Resonance
Authors: Pedram Hassan-Tash, Umar Ismail, Gurkirat Chana, Iain Kirkpatrick, Davinder S Jassal, Brett Hiebert, Amir Ravandi, Malek Kass, Ashish H Shah Conclusion: Stroke volume measured using NICaS strongly correlated with that from CMR. NICaS also
Whole-body bioimpedance monitoring for outpatient chronic heart failure follow up
Authors: Yusuke Tanino, Junya Shite, Oscar L Paredes, Toshiro Shinke, Daisuke Ogasawara, Takahiro Sawada, Hiroyuki Kawamori, Naoki Miyoshi, Hiroki Kato, Naoki Yoshino, Ken-ichi Hirata Conclusion: Hemodynamic parameters derived by NICaS are applicable for the non-invasive
Whole-body electrical bio-impendance is accurate in non invasive determination of cardiac output: A thermodilution controlled, prospective, double blind evaluation.
Authors: Guillermo Torre-Amione, Olga Milo, Edo Kaluski, Zvi Vered, Gad Cotter NICaS is a novel accurate noninvasive method for CO determination. The results of this study suggest that the NICaS might be more accurate than
The reliability of noninvasive cardiac system hemodynamic monitoring in the cardiac intensive care patient requiring mechanical circulatory support
Authors: Guido Tavazzi, Policlinico San Matteo Pavia Fondazione, A Fernandez-Gasalla, Ana Barradas-Pires, Yoseph Mebrate Conclusion: Both Pearson correlation and linear regression demonstrated an excellent correlation between CO measured by echo and the NICaS. NICaS looks
A noninvasive stroke volume monitoring for early detection of minimal blood loss: A pilot study
Authors: Danny Epstein, Ariel Guinzburg , Saar Sharon , Shai Kiso , Yuval Glick , Erez Marcusohn , Yehuda Daniel Glass , Asaf Miller , Sa’ar Minha , Ariel Furer Conclusion: Our study suggests that
Pregnancy outcomes of massively obese hypertensive gravidas
Authors: David G.Chaffin Jr. Jessica Granger Conclusion: In massively obese women with preexisting hypertension, hemodynamically guided treatment results in fewer cases of severe preeclampsia and fewer maternal and neonatal hospital days. For the full article
Perioperative sequential monitoring of hemodynamic parameters in patients with pheochromocytoma using the NICaS
Authors: Yayoi Matsuda, Hisaya Kawate, Shingo Shimada, Chitose Matsuzaki, Hiromi Nagata, Masahiro Adachi, Keizo Ohnaka, Masatoshi Nomura, Ryoichi Takayanagi Conclusion: The results of this study show the potential usefulness of sequential monitoring of hemodynamic status
Non invasive measurements of cardiac output (CO) and cardiac power index (CPI) by whole body bio impedance in patients with heart failure.
European Journal of Heart Failure Supplements ( 2012 ) UK Overview: Hemodynamic dysfunction is often used as part of the definition for heart failure (HF), predicts an adverse outcome and could be an important target
Non-invasive measurement of cardiac output by whole-body bio-impedance during dobutamine stress echocardiography: Clinical implications in patients with left ventricular dysfunction and ischemia
Authors: Gad Cotter, Marina Laitman, Edgar Sucher, Eli Peleg, Edo Kaluski, Ruth Wolf, Zvi Vered Conclusion: Measurement of CI by NICaS correlated well with Doppler-derived CI. The calculation of Cpi and TPRI changes during dobutamine
Noninvasive and simple assessment of cardiac output and pulmonary vascular resistance with whole-body impedance cardiography is useful for monitoring patients with pulmonary hypertension
Background: Cardiac Power Index (CPI) is a novel parameter calculated by CI*MAP and is considered to be a reliable indicator of myocardial contractility. Previous studies done by RHC technique demonstrated that CPI is the best
Maternal cardiac hemodynamics in normotensive VS pregnancies with preeclampsia – did we find a helpful tool?
Authors: Maya Ram, Anat Lavie, Shaul Lev, Yair Blecher, Yael Shulman, Tomer Avnon, Eran Weiner, Ariel Many Conclusion: The accuracy and noninvasiveness of the NICaS open a window of opportunity, aiding in evaluating and separating
Impedance cardiography revisited
Authors: G Cotter1, A Schachner2, L Sasson2, H Dekel2 and Y Moshkovitz3 Conclusion: The present CO results measured by the NICaS device indicate that, with regard to the accuracy of measuring the CO, the RIC
Impedance cardiography for cardiac output estimation reliability of wrist-to-ankle electrode configuration
Authors: Oscar Luis Paredes, Junya Shite, Toshiro Shinke, Satoshi Watanabe, Hiromasa Otake, Daisuke Matsumoto, Yusuke Imuro, Daisuke Ogasawara, Takahiro Sawada, Mitsuhiro Yokoyama Conclusion: The present study is aimed to test the effectiveness of the Non-Invasive
Cardiac hemodynamics before, during and after elective cesarean delivery, do we really know it all?
Authors: Anat Lavie, Maya Ram, Shaul Lev, Yair Blecher, Yael Shulman, Tomer Avnon, Eran Weiner, Ariel ManyConclusion: The researchers found that 3 min after delivery CO reaches a peak and TPR reaches a low. The
Baseline Granov-goor index predicts acute hemodynamic improvement during CRT optimization
Authors: Stefan Bogan, Israel Mazin, Igor Lipchenca, David Bar Lev , Osnat Gurevitz, Eyal Nof, Ilan Goldenberg, Sagit Ben Zekry, Michael Eldar, Michael Glikson, Roy Beinart Conclusion: Baseline GGI predicted acute hemodynamic improvement during NICaS
Cardiac hemodynamics in labor and postpartum – a new look into physiology
Authors: Eran Ashwal, Liran Hiersch, Yehuda Pauzner, Avital Wertheimer, Amir Aviram, Arnon Wiznitzer, Yariv Yogev Conclusion: The hemodynamic physiology of labor is characterized by significant changes between the latent phase and the active phase followed
Cardiac index in pregnancy – friend or foe
Authors: Maya Ram, Anat Lavie, Shaul Lev, Yair Blecher, Yael Shulman, Tomer Avnon, Eran Weiner, Ariel Many Conclusion: The purpose of the study was to assess the reliability of CO vs. CI in healthy pregnant
Cardiac Power Index is the best hemodynamic parameter to predict 6 month mortality in non septic ICU patients
Background: Cardiac Power Index (CPI) is a novel parameter calculated by CI*MAP and is considered to be a reliable indicator of myocardial contractility. Previous studies done by RHC technique demonstrated that CPI is the best
Cardiac Power Is the Strongest Hemodynamic Correlate of Mortality in Cardiogenic Shock: A Report from the SHOCK Trial Registry
Authors: Rupert Fincke , Judith S Hochman, April M Lowe, Venu Menon, James N Slater, John G Webb, Thierry H LeJemtel, Gad Cotter, SHOCK Investigators Conclusion: Cardiac power is a novel hemodynamic measure. By incorporating
Comparison of two methods of assessing total body water at sea level and increasing high altitude
Authors: C J Boos , D A Holdsworth, D P Hall, A Mellor, J O’Hara, D R Woods Overview: Assessment of hydration and nutritional status in clinical practice can be challenging and relies on a
Detection of left ventricular systolic dysfunction using a newly developed, laptop based, impedance cardiographic index
Authors: Yoseph Rozenman , Renee Rotzak , Robert P Patterson Results: A GGI cutoff of 10 was 89% sensitive and 96% specific for the detection of LVSD, confirming the excellent results of the training set.
Go with the flow
Overview: Thermodilution using a pulmonary artery catheter is considered the gold standard in measuring cardiac output. However. Drawbacks associated with the technique have prompted clinicians to seek less invasive options. But these alternatives have their
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