Pharma Clinical Trials

NICaS provides a real-time, continuously accurate1,2,3 and highly reproducible4 hemodynamic status including: stroke volume, cardiac output, total peripheral resistance, cardiac power index and total body water.

NICaS Can Help You To:

  • Assess inclusion criteria
  • Obtain real-time dose titration information
  • Monitor cardiac safety in both cardiovascular and non-cardiovascular trials
  • Evaluate drug efficacy and safety
  • Support single- or multi-site clinical trials
  • Document desired and adverse effects of candidate compounds
  • Reduce total trial time by facilitating patient recruitment
  • Decrease time-to-market of successful compounds

NICaS unique technology:
Allows easy application with only two sensors
Secures the data transfer to the core lab
Accurately assesses the smallest hemodynamic changes

  1. Paredes OL, Shite J, Shinke T, et al. Impedance cardiography for cardiac output estimation: reliability of wrist-to-ankle electrode configuration. Circ J. 2006;70(9):1164-1168. doi:10.1253/circj.70.1164
  2. Cotter G, Schachner A, Sasson L, Dekel H, Moshkovitz Y. Impedance cardiography revisited. Physiol Meas. 2006;27(9):817-827. doi:10.1088/0967-3334/27/9/005
  3. Cotter G, Moshkovitz Y, Kaluski E, et al. Accurate, noninvasive continuous monitoring of cardiac output by whole-body electrical bioimpedance. Chest. 2004;125(4):1431-1440. doi:10.1378/chest.125.4.1431
  4. Tita C, Gilbert EM, Van Bakel AB, et al. A Phase 2a dose-escalation study of the safety, tolerability, pharmacokinetics, and haemodynamic effects of BMS-986231 in hospitalized patients with heart failure with reduced ejection fraction. Eur J Heart Fail. 2017;19(10):1321-1332. doi:10.1002/ejhf.897

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