NICaS provides real-time continuously accurate1,2,3 and highly reproducible 4 hemodynamic status including: stroke volume, cardiac output, total peripheral resistance, cardiac power index and total body water

NICaS can help you:

> Assessment of inclusion criteria

> Attain real-time dose titration information

> Monitor cardiac safety in both cardiovascular and non-cardiovascular trials

> Evaluate drug efficacy and safety

> Support of single or multi site clinical trials

> Document desired and adverse effects of candidate compounds

> Reduce total trial time by facilitating patient recruitment

> Decrease time-to-market of successful compounds

NICaS unique technology:

> Allows easy application with only two sensors

> Secure data transfer to core lab

> Accurate assessment of the smallest hemodynamic changes

1. O. L. Paredes, et al Impedance Cardiography for Cardiac Output Estimation Circulation Journal 2006; 70:1164-1168 2. G. Cotter, et al Impedance Cardiography revisited Physiological Measurements 2006;27:817-827 3. Amram. J. Cohen, et al Accurate, Noninvasive ..Chest 2004; 1431-1440 4. Van De Water, et al., Chest 123: 2028-2033st 5. Tita et al A Phase 2a study of BMS-986231 in HFrEF Eur J Heart Fail. 2017 Jul 5

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